Immunotherapy Research Leads to "Triple Play" for Sanders-Brown

Posted: 1/25/2016
In the late 1990s, Donna Wilcock was exploring electrical activity in the epileptic brain as part of her undergraduate study in England, but her focus took an interesting turn as her studies into brain function deepened. "I began to wonder what, exactly, was going wrong in the brain as people developed dementia? What made them forget things?" said Wilcock. And that question bloomed into a career path focused on the triggers for a disease process that affects millions of people worldwide. After stints in several university laboratories in the U.S., Wilcock was recruited to the University of Kentucky Sanders-Brown Center on Aging in 2011 and is now associate... FULL STORY
Tags: Research, UK Sanders-Brown Center on Aging, Immunotherapy Research

Sanders-Brown Research Reveals Connection Between Tauopathies and

Posted: 1/20/2016
Assistant Professor Joe Abisambra, researcher at the University of Kentucky Sanders-Brown Center on Aging, has demonstrated for the first time that tau impairs protein synthesis — a key component in memory loss. "Though the exact mechanisms leading to memory loss in tauopathies are not yet known, the scientific community has acknowledged for years that in Alzheimer’s disease brains, tau associates with ribosomes, the hub of protein production. " said Abisambra. Ribosomes are our cellular "factories," tasked with making the proteins essential to proper cellular function. Using both in vivo and in vitro models, Abisambra and his lab were able to demonstrate that... FULL STORY
Tags: Research

UK Study Calls for Closer Examination of Transitional Care Management

Posted: 1/17/2016
Reducing excessive medical costs associated with high hospital readmission rates is a pillar of health care reform. From 2007 to 2011, as many as 19 percent of patients in the United States returned to hospitals less than a month after discharge, accounting for an estimated $15 million in preventable hospitalization costs. In an effort to prevent adverse outcomes for chronically ill and aging patients and reduce the burden of cost on the government, Medicare providers have implemented transitional care management programs (TCMs) as a bundled component of Medicare payment plans. TCMs comprise a broad set of services and interventions designed to ease the transition... FULL STORY
Tags: Research

New Dean of the UK College of Medicine

Posted: 1/4/2016
University of Kentucky Provost Tim Tracy and Executive Vice President for Health Affairs Dr. Michael Karpf announced Monday that Dr. Robert DiPaola, director of the Rutgers Cancer Institute of New Jersey and Vice Chancellor for Cancer Programs, Rutgers Biomedical and Health Sciences, has been named dean of the University of Kentucky College of Medicine. Dr. DiPaola is expected to assume the dean's position in the early spring, pending approval from the UK Board of Trustees. DiPaola was selected following a national search, which was co-chaired by Linda Van Eldik, director of UK's Sanders-Brown Center on Aging, and John Walz, dean of the College of Engineering... FULL STORY
Tags: Dean

Campbell Muscle Lab Gives Back to Heart Failure Patients

Posted: 12/14/2015
Every day throughout 2015, University of Kentucky physiologist Ken Campbell laced up his running shoes and took off for a 5-kilometer run, regardless of his schedule, plans or location. Regular running routes were plotted through his neighborhood and around the university’s campus. When traveling on business, he explored new territories and scenery on his runs. He also logged many miles running next to students on treadmills at the Johnson Center. Nothing stopped Campbell from completing a "5K a day."  Once ambivalent toward running, Campbell learned to embrace a daily jog as part of his personal commitment to cardiovascular health. In his laboratory work in the... FULL STORY

Markey Cancer Foundation Announces New President

Posted: 11/30/2015
The University of Kentucky Markey Cancer Foundation is pleased to announce the hiring of Michael Delzotti, CFRE, CSPG, as new president and chief executive officer. Delzotti will begin his new role in early December. The UK Markey Cancer Foundation serves as the fundraising arm for the UK Markey Cancer Center, the only National Cancer Institute-designated cancer center serving Kentucky and the surrounding Appalachian area. The Foundation underwent a nationwide search for their new president and chief executive officer this past summer. Delzotti comes to Markey from the world-renowned and number one-ranked University of Texas MD Anderson Cancer Center in Houston,... FULL STORY
Tags: Markey Cancer Center, Research

Cardiovascular Research Is Personal for UK's Lisa Cassis

Posted: 11/18/2015
For University of Kentucky Vice President for Research Lisa Cassis the drive to conduct meaningful research is personal.  “You don’t go into it for the money, you go into it because you want to help people,” Cassis said. The longtime UK professor chose to devote her career to cardiovascular research after watching her father battle heart disease for nearly 30 years. He suffered his first heart attack at age 51, went through three open heart surgeries, and was able to live until age 80 by managing his diet. However, Cassis says his lipid problems kept coming back no matter what he did. “I wanted to know why we aren’t able to help someone like... FULL STORY

UK Researchers Showcase Potential Therapy for Parkinson’s Disease at

Posted: 11/4/2015
Two University of Kentucky researchers will present evidence supporting a promising new therapy for Parkinson’s disease as part of a showcase of scientific research and innovation during the Michael J. Fox Foundation (MJFF) Parkinson’s Disease Therapeutics Conference. University of Kentucky College of Medicine professor Greg Gerhardt and associate professor Richard Grondin will today present “Therapeutic Development of siRNA Targeting Alpha-Synuclein” during the MJFF Parkinson’s Disease Therapeutics Conference in New York. The research studies whether targeting the alpha-synuclein protein is a safe approach to combating Parkinson’s disease. Gerhardt and Grondin were... FULL STORY
Tags: Parkinson's disease, Research

$1.6 Million Grant to Sanders-Brown Researcher Will Fund Study of

Posted: 10/27/2015
The National Institute of Neurological Disorders and Stroke (NINDS) has awarded Joe Abisambra, Ph.D., of the University of Kentucky Sanders-Brown Center on Aging a five-year, $1.6 million grant to study a group of diseases called tauopathies. Tauopathies are a group of more than 20 neurodegenerative disorders that affect nearly eight million Americans. These disorders all share one common characteristic: deposition of a protein called "tau" into sticky bundles inside brain cells. While Alzheimer's disease is the most-recognized tauopathy, Pick’s disease, and Chronic Traumatic Encephalopathy (originating from head trauma) are all a part of this expanding disease... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Research

UK Begins Work on Research Facility Designed to Address State's

Posted: 10/23/2015
Flanked by Gov. Steve Beshear and legislative leaders, University of Kentucky President Eli Capilouto Friday announced the beginning of work on a research facility unique in the country — a building dedicated to addressing health challenges and disparities in Kentucky. "Today, we commence building — not for ourselves, but for the future and the health of the Commonwealth of Kentucky," Capilouto said. "We have said that it is time for death to be a beggar in Kentucky. Today, we mark in a tangible and real way our intent to deliver on that promise." The research facility — scheduled for completion in spring 2018 — is a $265 million building. Half of... FULL STORY

Dutch named American Society of Virology President-Elect

Posted: 10/5/2015
University of Kentucky College of Medicine Professor Rebecca Dutch has been named President-Elect for the American Society for Virology (ASV). The American Society of Virology, comprised of over 3,000 members from around the globe, was founded in 1981 to provide a forum for discussion and collaboration for investigators of human, animal, insect, plant, fungal and bacterial viruses. ASV sponsors a large annual meeting, promotes communication about virology research to the broader community, and represents virologists on national and international scientific councils. Dutch will serve as the ASV president-elect for 2015-2016 and ASV president from 2016-2017. Dutch... FULL STORY
Tags: Faculty, Awards and Recognition, Biochemistry

Registration Open for Fifth Annual Markesbery Symposium Set for Nov. 20-21

Posted: 9/24/2015
UK Sanders-Brown Center on Aging (SBCoA) is hosting its fifth annual Markesbery Symposium on Aging and Dementia on Nov. 20-21. This two day program will offer sessions for both scientific and community audiences. Clinicians and researchers from the University of Kentucky and other institutions will come together to share current findings, trends and the latest updates on dementia and aging disorders, particularly as related to Alzheimer’s disease. The Markesbery Symposium is in honor of the late Dr. William R. Markesbery, the founder and long-time director of the UK Sanders-Brown Center on Aging and an internationally renowned expert on aging and dementia. On... FULL STORY
Tags: Research, UK Sanders-Brown Center on Aging