Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis.

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing.

Regulation of wingless signaling by the CKI family in Drosophila limb development.

Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.

PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation.

PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation.